Not S100A8 cell count indicates better outcome in gastric cancer patients. (A) Kaplan-Meier analysis of

Not S100A8 cell count indicates better outcome in gastric cancer patients. (A) Kaplan-Meier analysis of overall survival for high S100A8 cell count (> = 64) group and low S100A8 cell count (< 64) group in 125 gastric cancer patients. (B) Kaplan-Meier analysis of overall survival for high S100A9 cell count (> = 200) group and low S100A9 cell count (< 200) group in the same cohort of gastric cancer patients.Competing interests The authors have declared that no competing interests exist. Acknowledgments This work was supported by National Natural Science Foundation of China (No. 30471677 and 81141024) and National Key Technology R D Program (2011ZX09307-001-05). We thank Vladislava Juric and Mariia Yuneva from University of California, San Francisco for their help in preparing this manuscript. Author details Department of Surgery, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital Institute, Beijing, China. 2Department of Pathology, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital Institute, Beijing, China. 3Clinical Gastric Cancer Research Laboratory, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital Institute, Beijing, China. 4Tissue Bank, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital Institute, Beijing, China. 5Clinical Research Laboratory, Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital Institute, Beijing, China. 6 Department of General Surgery, Affiliated Hospital of Medical College Qingdao University, Shandong Province, China.Authors' contributions J-FJ and L-HZ conceived the design of the study and were in charge of its coordination. BF, X-YZ and Y-n J carried out the immunohistochemical assays. BF, L-HZ, X-HW and X-FX performed cell line assays. Y-QL, X-JC, HD, YH, Y-AL, WZ, A-PL and J-YL participated in the clinical materials collection. BF and L-HZ conducted statistical analysis. J-FJ, BF and L-HZ drafted the manuscript. Z-JN provided chronic appendicitis tissues with exacerbation. All authors read and approved the final manuscript. Received: 27 April 2012 Accepted: 7 July 2012 Published: 28 July 2012 References 1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D: Global cancer statistics. CA Cancer J Clin 2011, 61(2):69?0. 2. Karpeh MS, Leon L, Klimstra D, Brennan MF: Lymph node staging in gastric cancer: is location more important than Number? An analysis of 1,038 patients. Ann Surg 2000, 232(3):362?71.Conclusions S100A9 was specifically expressed in inflammatory cells infiltrating gastric cancer tissues and chronic gastritis tissues. Presence of S100A9-positive inflammatory cellsFan et al. BMC Cancer 2012, 12:316 http://www.biomedcentral.com/1471-2407/12/Page 11 of3.4. 5. 6. 7. 8.9.10.11.12.13.14.15. 16. 17.18.19.20.21.22.23.24.25.Smith DD, Schwarz RR, Schwarz RE: Impact of total lymph node count on staging and survival after gastrectomy for gastric cancer: data from a large US-population database. J Clin Oncol 2005, 23(28):7114?124. Fatourou E, Ziogas D, Baltogiannis G: Moving from lymph node metastasis in gastric cancer to biological markers. World J PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26740125 Surg 2010, 34(5):1140?141. Roukos DH: Genome-wide Actinomycin D manufacturer association studies: how predictable is a person’s cancer risk? Ex.