Sease phenotype, the studies are variable in their conclusions. A number of contributeSease phenotype, the

Sease phenotype, the studies are variable in their conclusions. A number of contribute
Sease phenotype, the studies are variable in their conclusions. Quite a few contribute to the disease phenotype, the studies are variable in their conclusions. Many variables could explain these discrepancies, like various age-ranges, geographical factors could clarify these discrepancies, such as distinct age-ranges, geographical lolocation, ethnicity, unique obesity degrees, the the fairly low number of subjects cation, ethnicity, unique obesity degrees, and andrelatively low quantity of subjects anaanalyzed. lyzed.Table 1. Studies characterizing the gut microbiome in subjects with PWS. Table 1. Research characterizing the gut microbiome in subjects with PWS.Author, Year Dahl, 2021 [28]Author, YearStudy TypeStudy TypeAimAim Target Population PWS adults 34.9 Mean age vs. controlsTarget PopulationDahl, 2021 [28]Observational,cross-sectional Observational, PWS adults vs. cross-sectional controls10.2 years (n = 25) Imply ageLower abundance of Blautia. Mean age 34.9 10.2abundance of Blautia. Greater RF39 (Tenericutes Lower years phyla), Ruminococcaceae, Greater RF39 (Tenericutes phyla), Ruminococcaceae, (n = 25) Alistipes, Erysipelotrichacaea, Alistipes, Erysipelotrichacaea, Parabacteriodes, OdoribacParabacteriodes, Odoribacter. Higher Prevotella and reduce Imply age Oscillospira. Greater Candida and six.2 years Larger Prevotella and lowerlower Saccharomyces. CanOscillospira. Larger (range 37) dida and reduced Saccharomyces. Hyperphagia scores asHyperphagia scores associated (n = 25) with -diversity. sociated with fungal fungal -diversity.ResultsResultsGRADE 2+GRADE 2+ter.2++ ((R)-Leucine custom synthesis variety 37) (n = 25) Imply age Lower phylogenetic diversity, Mean age Garcia-Ribera, Observational, PWS obese vs.PWS 12.0 four.0 years lower Alistipes and Murimonas PWS obese vs. Decrease phylogenetic diversity, lower Alistipes and 2+ Garcia-Ribera, Observational, 12.0 4.0 years 2020 [26] cross-sectional regular weight (variety 58) abundance, and larger PWS typical Murimonas abundance, and higher Klebsiella abun2+ (n = 31) Klebsiella abundance in obesity. 2020 [26] cross-sectional (range 58) weight dance in obesity. (n = 31) Higher phylogenetic diversity Mean age phylogenetic diversity in PWS. in PWS. Imply age Larger Observational, PWS obese vs. obese Olsson, 2019 [25] Olsson, 2019 Observational, PWS obese vs. 29.four 7.eight years Larger Akkermansia, 2++ cross-sectional controls 29.4 7.8 years Greater Akkermansia, Desulfovibrio, and Archaea. and Archaea. 2++ (n = 17) Desulfovibrio, [25] cross-sectional obese controls (n = 17) Lower Dorea. Reduce Dorea. Mean age Imply age PWS childrenPWS young children with No important variations in Zhang, 2015 9.3 years No key differences in microbiota diversity and com9.3 years Zhang, 2015 [29] 6-Chloromelatonin web Intervention microbiota diversity and 1- Intervention with obesity vs.obesity vs. obese 1- (variety 56) [29] (variety 56) position. composition. controls obese controls (n = 17) (n = 17) Target populationrefers to subjects with PWS in thethe study. Evidence levels have already been classified in accordance together with the population refers to subjects with PWS in study. Evidence levels have already been classified in accordance with all the GRADE Target methodology [38]. GRADE methodology [38].Peng, 2020 Observational, PWS young children Peng, 2020 [27] cross-sectional [27] cross-sectional vs. controlsObservational,PWS kids vs. 6.two years controls2++The first study describing the PWS-associated gut microbiome was published in 2015 by Zhang etstudy describing the PWS-associated gut microbiome was p.