female) have been enrolled. A detailed neuropsychological (NP) assessment was performed. PCSK9 levels were measured

female) have been enrolled. A detailed neuropsychological (NP) assessment was performed. PCSK9 levels were measured with ELISA. Outcomes: Men had drastically larger short-term memory, executive function and praxic and mental representation skills, as reflected by Forward Digit Span (FDS) (P = 0.005), Trail Making Test-A (TMT-A) (P = 0.047), Clock Drawing Test (0.016). Endogenous PCSK9 levels had been higher in female (P = 0.005). On linear regression analysis PCSK9 predicts brief term memory only in females (Beta = 0.408, P = 0.001), with an interaction among PCSK9 and gender (P = 0.004 for interaction PCSK9 by sex). The association of PCSK9 with FDS in female was partially mediated by waist circumference (mediation impact 8.5 ). Conclusions: In individuals at higher CV threat short term memory was straight associated to PCSK9 levels only in females, revealing the relevance of sex in this Kainate Receptor Antagonist manufacturer partnership. The association of PCSK9 with memory function can be mediated, no less than in portion, by waist circumference.PB1290|Transferability in the ETP-based APC Resistance Assay on the ST Genesia Method L. Morimont1,2; M. Didembourg1; J.-M. Dogn; A. Carlo3; J. Douxfils1,University of Namur, Department of Pharmacy, Namur Thrombosisand Hemostasis Center (NTHC), Namur Research Institute for Life Sciences (NARILIS), Namur, Belgium; 2QUALIblood S.A., Namur, Belgium; 3Diagnostica Stago, Asni es-sur-Seine, France Background: Regulatory bodies propose assessing the endogenous thrombin potential (ETP)-based activated protein C (APC) resistance assay for the duration of the development of combined oral contraceptives (COC) in girls. In 2019, this assay was validated on the Calibrated Automated Thrombogram (CAT) device utilizing commercially accessible reagent to ensure batch-to-batch traceability, and reproducibility on the technique more than time. Nonetheless, in view of itsPB1289|Sex-specific Association of Endogenous PCSK9 with Memory Function in Elderly Subjects at High CV Risk P. Simeone1; F. ATR Activator MedChemExpress Vadini2; R. Tripaldi1; R. Liani1; S. Ciotti1; A. Di Castelnuovo ; F. Cipollone ; F. Santilli1 three 1screening possible, its implementation in clinical routine is essential. Aims: This study aimed at implementing the ETP-based APC resistance assay on the automated ST Genesia program (Stago, France), making use of reagent STG-ThromboScreen -TM (TS -TM) (Stago, France) with exogenous APC added (Stago, France). Techniques: Healthy pooled plasma (HPP) constituted of 20 healthier people (ten males and 10 ladies not applying COC, not carrier of FV Leiden or G20210A mutation) was utilized to define APC concentration major to 90 of inhibition of the ETP. Dose-response curves had been performed on two distinct batches of TS -TM. The intra- (N = 5) and inter-run (N = 10) variability had been assessed on three samples: STGRefPlasma TS, STG-QualiTest Norm TS and STG-QualiTest Higher TS. STG-QualiTest Low TS was not assessed as thrombin generation was totally inhibited in presence of APC. Twenty samples from healthier men and women have been analyzed to define reference ranges.Department of Medicine and Aging, and Center for Advanced Psychoinfectivology Service, Pescara Common Hospital, Pescara, Italy; Mediterranea Cardiocentro, Naples, ItalyStudies and Technologies (CAST), By means of Luigi Polacchi, Chieti, Italy;2Background: Growing evidence indicates that cognitive decline and cardiovascular diseases (CVDs) share prevalent vascular threat aspects. Protease proprotein convertase subtilisin/kexin variety 9 (PCSK9) is associated with CV disease threat and has been also invo