8) 77 (40.1) 51 (26.six) 5 (2.6) 32 (16.7) 118 (61.five) 16 (eight.three)110 (57.3) 97

8) 77 (40.1) 51 (26.six) 5 (2.6) 32 (16.7) 118 (61.five) 16 (eight.three)110 (57.3) 97 (50.1) 68 (35.4) 12 (six.three) 26 (13.five) 132 (68.8) 24 (12.5)0.206 0.01 ,0.0001 0.044 0.0002 0.014 0.26.two(0.30) 129.7(1.04) 80.1(0.64) 5.two(0.066) 1.7(0.076) 82.4(1.11) 1.7(0.041) 93.6(1.63)26.five(0.31) 127.7(1.04) 78.9(0.65) 5.2(0.066) 1.8(076) 81.6(1.11) 1.7(0.041) 94.9(1.64)26.six(0.30) 128.four(1.04) 79.six(0.65) 5.two(0.066) 1.eight(076) 82.eight(1.11) 1.8(0.041) 94.5(1.64)26.eight(0.31) 132.0(1.05) 81.1(0.65) 5.four(0.067) two.2(077) 90.three(1.12) 1.7(0.041) 90.9(1.65)0.507 0.023 0.104 0.170 ,0.0001 ,0.0001 0.852 0.Calculated creatinine clearance, ml/min/1.73mP-value for trend across the quartiles
eight) 77 (40.1) 51 (26.6) five (two.6) 32 (16.7) 118 (61.5) 16 (eight.3)110 (57.three) 97 (50.1) 68 (35.four) 12 (6.three) 26 (13.five) 132 (68.8) 24 (12.five)0.206 0.01 ,0.0001 0.044 0.0002 0.014 0.26.2(0.30) 129.7(1.04) 80.1(0.64) five.two(0.066) 1.7(0.076) 82.4(1.11) 1.7(0.041) 93.six(1.63)26.5(0.31) 127.7(1.04) 78.9(0.65) five.2(0.066) 1.8(076) 81.six(1.11) 1.7(0.041) 94.9(1.64)26.6(0.30) 128.four(1.04) 79.6(0.65) 5.two(0.066) 1.eight(076) 82.8(1.11) 1.eight(0.041) 94.5(1.64)26.eight(0.31) 132.0(1.05) 81.1(0.65) 5.four(0.067) 2.two(077) 90.3(1.12) 1.7(0.041) 90.9(1.65)0.507 0.023 0.104 0.170 ,0.0001 ,0.0001 0.852 0.Calculated creatinine clearance, ml/min/1.73mP-value for trend across the quartiles is offered. Values are imply (SD) or variety of participants ( ) as proper. doi:10.1371/journal.pone.0079682.tPLOS 1 | plosone.orgHeritability of Uremic Retention MoleculesTable 2. Baseline traits by quartiles of p-cresyl sulfate.P-Cresyl Sulfate, mmol/L Traits Qualities n ( ) Men Hypertension Antihypertensive drug intake Diabetes mellitus Current D5 Receptor Compound smokers Existing drinkers History of CV illness Age-adjusted qualities Body mass index, kg/m2 Systolic blood pressure, mmHg Diastolic blood pressure, mmHg Serum cholesterol, mmol/L Triglycerides, mmol/L Serum creatinine, mmol/L Measured creatinine clearance, ml/min/1.73m2 Calculated creatinine clearance, ml/min/1.73m2 26.6 (0.31) 131.0 (1.07) 80.four (0.67) 5.two (0.068) 1.9 (0.079) 82.9 (1.16) 1.78 (0.041) 96.7 (1.66) 26.five (0.31) 128.4 (1.07) 79.7 (0.66) 5.two (0.067) 1.8 (078) 82.7 (1.15) 1.71 (0.041) 94.4 (1.65) 26.six (0.31) 128.7 (1.06) 80.two (0.66) 5.3 (0.067) 1.eight (078) 83.six (1.15) 1.78 (0.041) 94.1 (1.65) 26.3 (0.32) 129.five (1.09) 79.five (0.68) 5.three (0.069) 1.9 (080) 88.3 (1.18) 1.63 (0.042) 88.five (1.68) 0.749 0.317 0.775 0.960 0.877 0.0019 0.041 0.0062 101 (53.7) 72 (38.6) 40 (21.three) 6 (3.2) 44 (23.four) 135 (71.8) 16 (eight.5) 91 (48.four) 61 (32.three) 30 (16.0) two (1.1) 48 (25.five) 138 (73.4) 17 (9.0) 92 (49.two) 84 (44.9) 56 (29.9) 9 (four.eight) 37 (19.eight) 135 (72.2) 13 (7.0) 91 (48.4) 89 (47.three) 60 (31.9) 7 (three.7) 23 (12.2) 109 (58.0) 25 (13.three) 0.35 0.08 0.0012 0.35 0.0029 0.0048 0.20 ,7.36 (n = 188) 7.363.02 (n = 188) 13.031.43 (n = 187) .21.43 (n = 188)PThe P-value for trend across the quartiles is provided. Values are mean6SD or number of participants ( ) as acceptable. doi:ten.1371/journal.pone.0079682.tSerum concentrations of indoxyl sulfate and p-cresyl sulfate had been also discovered to be greater in men. Even though this locating may well reflect differences in the composition of gut microbiota amongst males and ladies, accessible proof argues against this explanation [3]. Gender differences in intestinal absorption, metabolismand/or renal clearances could also be involved, but supporting proof, no less than in humans, is lacking so far. Smoking and alcohol consumption had been related with reduced indoxyl sulfate levels and p-cresyl sulfate, though for the latter, the association was lost in multivariable analyses. The mechanisms underlying these associations are unclear. Even though a directTable three. Determinants of indoxyl sulfate and p-cresyl sulfate.Log Indoxyl sulfate N Variance explained by pedigree Variance explained by fixed effects Parameter estimates Intercept Male sex Age, years Age squared, years Existing smoking Present alcohol intake Standard systolic blood ALDH1 custom synthesis pressure Log triglycerides, mmol/L Serum creatinine, mmol/LLog p-Cresyl sulfate 751 0.046 0.069 0.91660.247*** 0.094560.0387*773 0.054 0.153 0.26860.0782*** 0.030260.* * *20.0046160.*20.012860.00605* 0.000.