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ONCOLOGY LETTERS six: 1140-1146,Composition
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ONCOLOGY LETTERS six: 1140-1146,Composition and prospective anticancer activities of vital oils obtained from myrrh and frankincenseYINGLI CHEN1,2, CHUNLAN ZHOU1, ZHENDAN GE1, YUFA LIU3, YUMING LIU4, WEIYI FENG5, SEN LI1, GUOYOU CHEN1 and TAIMING WEI1,College of Pharmacy, Harbin Health-related University-Daqing, Daqing, Heilongjiang 163319; Biopharmaceutical Institute on the Heilongjiang Academy of Healthcare Sciences, Harbin, Heilongjiang 158000; three Division of Chemistry, Chemical Engineering and Material Science, Shandong Typical University, Jinan, Shandong 250000; 4College of Chemistry and Chemical Engineering, Tianjin University of Technologies, Tianjin 300000; 5College of Medicine, Xi’an Jiaotong University, Xi’an, Shanxi 710001, P.R. China Received February 8, 2013; Accepted July 26, 2013 DOI: 10.3892/ol.2013.Abstract. The present study aimed to investigate the composition and prospective anticancer activities of critical oils obtained from two species, myrrh and frankincense, by hydrodistillation. Bax Inhibitor supplier Utilizing gas chromatography-mass spectrometry (GC-MS), 76 and 99 elements were identified inside the myrrh and frankincense important oils, respectively, with all the most abundant elements, 2-Cyclohexen-1-one, 4-ethynyl-4-hydroxy-3,five,5-trimethyl- and n-Octylacetate, accounting for 12.01 and 34.66 , respectively. The effects in the two crucial oils, independently and as a mixture, on 5 tumor cell lines, MCF-7, HS-1, HepG2, HeLa and A549, have been investigated using the MTT assay. The outcomes indicated that the MCF-7 and HS-1 cell lines showed enhanced sensitivity to the myrrh and frankincense essential oils compared using the remaining cell lines. Furthermore, the anticancer effects of myrrh had been markedly increased compared with those of frankincense, nevertheless, no considerable synergistic effects were identified. The flow cytometry benefits indicated that apoptosis might be a significant contributor for the biological efficacy of MCF7 cells. Introduction Commiphora myrrha has a yellow oleo-gum resin that exists in its stem and is employed worldwide for the production of myrrh, particularly in China and Egypt. The constituents of myrrh, involve volatile oil (2-8 ), resin (23-40 ), gum (40-60 ) and bitter principles (10-25 ). Preceding research have shown thatmyrrh exhibits cytotoxic, analgesic, antiinflammatory, anticancer, antiparasitic and hypolipidemic activities (1-4). Frankincense is definitely an aromatic resin obtained from trees of your genus Boswellia and has been hypothesized to exhibit quite a few well being supporting properties, which includes the treatment of rheumatoid arthritis and antiinflammatory, antibacterial, antifungal and anticancer activities (5-8). Frankincense oil is ready by the steam distillation of frankincense gum resin and is often applied in aromatherapy practices. In line with preceding research, the constituents of frankincense oil vary in line with the climate, harvest conditions and geographical sources of your frankincense resin (9). Notably, these two resinous drugs are normally prescribed simultaneously in classic Chinese medicine and are primarily administered for the remedy of blood stagnation and inflammation ailments, at the same time as for the relief of swelling and pain (ten). A preceding study identified that the mixture of frankincense and myrrh oils exhibited synergistic effects on Cryptococcus neoformans and Pseudomonas aeruginosa (11). The present study investigated the chemical composition of hyd.
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