Product Name :
m-PEG6-Amine
Description:
m-PEG6-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG6-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
CAS:
184357-46-8
Molecular Weight:
295.37
Formula:
C13H29NO6
Chemical Name:
2,5,8,11,14,17-hexaoxanonadecan-19-amine
Smiles :
COCCOCCOCCOCCOCCOCCN
InChiKey:
JDTWBXXBTWYNAT-UHFFFAOYSA-N
InChi :
InChI=1S/C13H29NO6/c1-15-4-5-17-8-9-19-12-13-20-11-10-18-7-6-16-3-2-14/h2-14H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
m-PEG6-Amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.{{Glatiramer} medchemexpress|{Glatiramer} Technical Information|{Glatiramer} Description|{Glatiramer} manufacturer|{Glatiramer} Epigenetic Reader Domain} m-PEG6-Amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).{{Penicillin G} MedChemExpress|{Penicillin G} Bacterial|{Penicillin G} Technical Information|{Penicillin G} Purity|{Penicillin G} supplier|{Penicillin G} Autophagy} |Product information|CAS Number: 184357-46-8|Molecular Weight: 295.37|Formula: C13H29NO6|Chemical Name: 2,5,8,11,14,17-hexaoxanonadecan-19-amine|Smiles: COCCOCCOCCOCCOCCOCCN|InChiKey: JDTWBXXBTWYNAT-UHFFFAOYSA-N|InChi: InChI=1S/C13H29NO6/c1-15-4-5-17-8-9-19-12-13-20-11-10-18-7-6-16-3-2-14/h2-14H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32472497 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.|References:|Herve Bouchard, et al. Peptidic linkers and cryptophycin conjugates, useful in therapy, and their preparation. WO2018206635A1.Austin G Wardrip, et al. Length-Independent Charge Transport in Chimeric Molecular Wires. Angew Chem Int Ed Engl. 2016 Nov 7;55(46):14267-14271.Products are for research use only. Not for human use.|
