Product Name :
PROTAC Bcl2 degrader-1
Description:
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.
CAS:
2378801-85-3
Molecular Weight:
941.84
Formula:
C45H45BrN6O10S
Chemical Name:
N’-(2-{8-[(4-bromophenyl)sulfanyl]-2, 4-dioxo-3-azatricyclo[7.3.1.0, ]trideca-1(13), 5, 7, 9, 11-pentaen-3-yl}ethyl)-N-{2-[2-(2-{[2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxo-2, 3-dihydro-1H-isoindol-4-yl]amino}ethoxy)ethoxy]ethyl}hexanediamide
Smiles :
O=C(CCCCC(=O)NCCN1C(=O)C2=CC=C(SC3C=CC(Br)=CC=3)C3=CC=CC(=C32)C1=O)NCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O
InChiKey:
IUSLKFLLLNNOGR-UHFFFAOYSA-N
InChi :
InChI=1S/C45H45BrN6O10S/c46-27-11-13-28(14-12-27)63-35-17-15-32-39-29(35)5-3-6-30(39)42(57)51(43(32)58)22-19-48-36(53)9-1-2-10-37(54)49-21-24-62-26-25-61-23-20-47-33-8-4-7-31-40(33)45(60)52(44(31)59)34-16-18-38(55)50-41(34)56/h3-8,11-15,17,34,47H,1-2,9-10,16,18-26H2,(H,48,53)(H,49,54)(H,50,55,56)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{BI 1015550} site|{BI 1015550} Metabolic Enzyme/Protease|{BI 1015550} Technical Information|{BI 1015550} In stock|{BI 1015550} custom synthesis|{BI 1015550} Epigenetics}
Shelf Life:
≥12 months if stored properly.{{Gap 26} web|{Gap 26} Gap Junction Protein|{Gap 26} TGF-beta/Smad|{Gap 26} Protocol|{Gap 26} In stock|{Gap 26} manufacturer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24220671
Additional information:
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1.|Product information|CAS Number: 2378801-85-3|Molecular Weight: 941.84|Formula: C45H45BrN6O10S|Chemical Name: N’-(2-{8-[(4-bromophenyl)sulfanyl]-2, 4-dioxo-3-azatricyclo[7.3.1.0, ]trideca-1(13), 5, 7, 9, 11-pentaen-3-yl}ethyl)-N-{2-[2-(2-{[2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxo-2, 3-dihydro-1H-isoindol-4-yl]amino}ethoxy)ethoxy]ethyl}hexanediamide|Smiles: O=C(CCCCC(=O)NCCN1C(=O)C2=CC=C(SC3C=CC(Br)=CC=3)C3=CC=CC(=C32)C1=O)NCCOCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O|InChiKey: IUSLKFLLLNNOGR-UHFFFAOYSA-N|InChi: InChI=1S/C45H45BrN6O10S/c46-27-11-13-28(14-12-27)63-35-17-15-32-39-29(35)5-3-6-30(39)42(57)51(43(32)58)22-19-48-36(53)9-1-2-10-37(54)49-21-24-62-26-25-61-23-20-47-33-8-4-7-31-40(33)45(60)52(44(31)59)34-16-18-38(55)50-41(34)56/h3-8,11-15,17,34,47H,1-2,9-10,16,18-26H2,(H,48,53)(H,49,54)(H,50,55,56)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (26.54 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.Products are for research use only. Not for human use.|
