Product Name :
G907
Description:
G907 is a selective small-molecule antagonist of ATP-binding cassette (ABC) transporter, MsbA. It inhibits purified E. coli MsbA in amphipols with an IC50 of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket. Bactericidal activity.
CAS:
2244035-16-1
Molecular Weight:
433.93
Formula:
C26H24ClNO3
Chemical Name:
(2E)-3-{6-[1-(2-chloro-6-cyclopropylphenyl)ethoxy]-4-cyclopropylquinolin-3-yl}prop-2-enoic acid
Smiles :
CC(OC1=CC2=C(C3CC3)C(=CN=C2C=C1)/C=C/C(O)=O)C1=C(Cl)C=CC=C1C1CC1
InChiKey:
HOMQCLNBKVHZGD-FMIVXFBMSA-N
InChi :
InChI=1S/C26H24ClNO3/c1-15(25-20(16-5-6-16)3-2-4-22(25)27)31-19-10-11-23-21(13-19)26(17-7-8-17)18(14-28-23)9-12-24(29)30/h2-4,9-17H,5-8H2,1H3,(H,29,30)/b12-9+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
G907 is a selective small-molecule antagonist of ATP-binding cassette (ABC) transporter, MsbA.{{Riboflavin} site|{Riboflavin} Bacterial|{Riboflavin} Purity & Documentation|{Riboflavin} Data Sheet|{Riboflavin} custom synthesis|{Riboflavin} Autophagy} It inhibits purified E. coli MsbA in amphipols with an IC50 of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket. Bactericidal activity.|Product information|CAS Number: 2244035-16-1|Molecular Weight: 433.93|Formula: C26H24ClNO3|Chemical Name: (2E)-3-{6-[1-(2-chloro-6-cyclopropylphenyl)ethoxy]-4-cyclopropylquinolin-3-yl}prop-2-enoic acid|Smiles: CC(OC1=CC2=C(C3CC3)C(=CN=C2C=C1)/C=C/C(O)=O)C1=C(Cl)C=CC=C1C1CC1|InChiKey: HOMQCLNBKVHZGD-FMIVXFBMSA-N|InChi: InChI=1S/C26H24ClNO3/c1-15(25-20(16-5-6-16)3-2-4-22(25)27)31-19-10-11-23-21(13-19)26(17-7-8-17)18(14-28-23)9-12-24(29)30/h2-4,9-17H,5-8H2,1H3,(H,29,30)/b12-9+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.{{Temsirolimus} MedChemExpress|{Temsirolimus} Autophagy|{Temsirolimus} Purity & Documentation|{Temsirolimus} References|{Temsirolimus} custom synthesis|{Temsirolimus} Autophagy} 33 mg/mL (192.PMID:32506966 04 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
