Product Name: C2orf57 Polyclonal Antibody
Applications: WB, IHC-P, IF(IHC-P)
Reactivity: Human
Conjugation: Unconjugated
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human C2orf57
Clonality: Polyclonal
CAS NO: 625115-55-1
Product: Cevimeline (hydrochloride hemihydrate)
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Synonyms: Chromosome 2 open reading frame 57; Hypothetical protein LOC165100; MGC35154; Uncharacterized protein C2orf57; CB057_HUMAN.
Background: C2orf57, also known as MGC35154, is a 395 amino acid protein encoded by a gene that maps to human chromosome 2q37.1. As the second largest human chromosome, chromosome 2 makes up approximately 8% of the human genome and contains 237 million bases encoding over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstré°‰ syndrome, is related to mutations in the ALMS1 gene. Chromosome 2 contains a probable vestigial second centromere as well as vestigial telomeres, which gives credence to the hypothesis that human chromosome 2 formed as a result of an ancient fusion of two ancestral chromosomes, which are still present in modern day apes.
PubMed ID:http://jpet.aspetjournals.org/content/273/1/257
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