Product Name: C5a anaphylatoxin Polyclonal Antibody, Cy7 Conjugated
Applications: IF(IHC-P)
Reactivity: Mouse
Conjugation: Cy7
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from mouse C5a (725-770aa)
Clonality: Polyclonal
CAS NO: 249503-25-1
PKC412
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: C5; He; C5a; Complement C5; Hemolytic complement; Hc
Background: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
PubMed ID:http://jpet.aspetjournals.org/content/276/3/958
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