Product Name: C9orf169 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated
Applications: IF(IHC-P)
Reactivity: Human
Conjugation: ALEXA FLUOR® 555
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human C9orf169
Clonality: Polyclonal
CAS NO: 248919-64-4
Product: Tenapanor
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: C9orf169; Chromosome 9 open reading frame 169; CI169_HUMAN; MGC59937; UPF0574 protein C9orf169.
Background: C9orf169 (chromosome 9 open reading frame 169) is a 423 amino acid single-pass membrane protein that belongs to the clpA/clpB family and torsin subfamily. The gene encoding C9orf169 maps to human chromosome 9q34.3. Chromosome 9 consists of about 145 million bases, represents 4% of the human genome and encodes nearly 900 genes. Thought to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias.
PubMed ID:http://jpet.aspetjournals.org/content/285/2/464
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