Product Name: Caspase 3 Polyclonal Antibody, ALEXA FLUOR® 594 Conjugated
Applications: IF(IHC-P), IF(ICC)
Reactivity: Human, Mouse, Rat, Bovine, Goat
Conjugation: ALEXA FLUOR® 594
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human Caspase 3(Active)
Clonality: Polyclonal
CAS NO: 1215370-87-8
Product: Butylhydroxyanisole
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: CPP32; SCA-1; CPP32B; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; CASP3
Background: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a 216-Asp-|-Gly-217 bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
PubMed ID:http://jpet.aspetjournals.org/content/294/1/387
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