Product Name: Cathepsin L Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated
Applications: IF(IHC-P), IF(ICC)
Reactivity: Human, Mouse, Rat
Conjugation: ALEXA FLUOR® 350
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from mouse capsin L1 proprotein
Clonality: Polyclonal
CAS NO: 39011-90-0
Product: TAK-960
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: fs; MEP; nkt; Ctsl1; 1190035F06Rik; Cathepsin L1; Cathepsin L; Major excreted protein; p39 cysteine proteinase; Ctsl
Background: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene.
PubMed ID:http://jpet.aspetjournals.org/content/296/2/412
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