E subunit beta, mitochondrialProcesses/Information pathways Processes Processes Processes Information Pathways Transport Metabolism Metabolism Metabolism Metabolism Metabolism Metabolism Processes Processes Processes Information pathways Information pathways Transport 52/6.22 59.5/4.875 63/6.2 15.5/2.82 38/7.51 40.5/6.885 45/5.72 45/8.05 27/4.48 41/6.58 42.5/3.96 30/5.885 93/5.43 69.5/5.Pyruvate dehydrogenase E1 component subunit beta, mitochondrialHydroxyacid oxidase217/Medium-chain specific acyl-CoA dehydrogenase, mitochondrialHomogentisate 1,2-dioxygenaseSarcosine dehydrogenase, mitochondrialBeta-lactamase-like proteinSerine/threonine-protein phosphatase PP1-alpha catalytic subunit317/CatalaseAldehyde dehydrogenase family 1 member L1 100/5.Alpha-aminoadipic semialdehyde dehydrogenase324/60 kDa heat shock protein, mitochondrialCoatomer subunit deltaATP synthase subunit delta, mitochondrialAlcohol dehydrogenase 23115181 [NADP+]Sorbitol dehydrogenaseIsovaleryl-CoA dehydrogenase, mitochondrial 42.5/6.Ornithine aminotransferase, mitochondrialCreatine kinase U-type, mitochondrialLactoylglutathione lyasePhosphotriesterase-related protein40S ribosomal protein SAProteasome subunit beta type-385/386/Meprin A subunit alphaSerum albuminProteomic of F Renal Metabolism in Micea Experimental molecular weight (kDa)/pI of protein spot in the gel (Mean of min. and max.) based on the coordinates of landmark proteins. bTitle Loaded From File theoretical molecular weight (kDa)/pI of theoretical protein. cNumber of Benzimidazole (DRB)] in nuclear extracts [11]. Thus, the presence of W049 protein peptides identified and score. dDifferences in expression in relation to 129P3/J mice (Q down-modulation; q up-modulation); Individual P value after ANOVA. eIdentification is based on protein ID from IPI (international protein index) protein database (http://www.uniprot.org/). fCategory of protein based on its primary biological function according to Rison (2000) [18]. doi:10.1371/journal.pone.0053261.tTable 2. Expression of differentially significant kidney proteins between 10 ppmF A/J vs 10 ppmF 129P3/J mice.a c bSpot n6. 15.5/2.82 40/6.625 42.5/5.94 43/8.25 42.5/6.6 45/5.72 42/6.11 34/6.415 43/9.1 35.5/4.915 38.5/5.675 52.5/6.34 58/7.445 53.5/5.68 37/5.905 28/8.615 37/5.505 41/5.535 43/6.715 45/5.72 42/6.015 27/4.48 27/4.55 69.5/4.645 26.5/10.135 59.5/5.73 89.5/5.5 99.5/3.99 49.5/5.445 57.5/4.76 69.5/5.42 39.3/6.0 20.7/5.25 23.3/5.1 56.5/5.3 25.3/8.88 54.3/5.7 77.2/5.9 92.5/4.74 47.2/5.6 51.9/5.2 65.9/5.53 13/403 7/85 16/362 11/187 24/515 13/554 9/109 15/635 45.8/5.7 43/6.3 33.1/5.54 7/216 12/535 10/255 7/245 37/365 36.4/5.7 10/705 28.5/7.78 13/353 51.7/5.0 4/188 52.5/5.9 13/374 59.7/7.7 6/103 55.9/6.0 13/374 37.4/5.9 9/122 q129 (0.018) q129(0.005) q129(0.032) q129(0.037) Q129(0.022) Q129(0.017) Q129(0.002) Q129(0.016) Q129(0.021) Q129(0.024) Q129(0.041) Q129(0.001) Q129(0.005) Q129(0.041) Q129(0.050) Q129(0.043) Q129(0.002) Q129(0.011) Q129(0.016) Q129(0.028) Q129(0.020) 35.3/5.3 9/488 q129(0.003) 49/8.2 3/107 q129(0.035) 32.8/6.1 8/181 q129(0.039) 44/6.0 2/66 q129(0.047) 50/7.9 8/142 q129(0.015) P97807 Q9DBL1 Q78JT3 Q9CZU6 Q91XE4 P62137 Q9DBF1 P24270 P17563 Q91V76 Q8BH95 P16125 Q9Z0S1 Q9JHI5 P29758 P11930 Q9CPU0 Q99PT1 Q9JIL4 Q9WTP7 P27773 P28825 Q91V38 Q99JY9 P21614 P07724 43/6.3 15/559 q129(0.047) P50247 43.6/7.7 15/541 q129(0.001) P45952 45.8/5.9 18/831 q129(0.013) Q99JW2 37.8/6.3 4/146 q129(0.016) Q8K157 51.7/5.0 4/188 q129(0.040) P56480 Metabolism Metabolism Metabolism Metabolism Metabolism Metabolism Metabolism Metabolism Metabolism ProcessesProteinMw (kDa)/pI Expt.E subunit beta, mitochondrialProcesses/Information pathways Processes Processes Processes Information Pathways Transport Metabolism Metabolism Metabolism Metabolism Metabolism Metabolism Processes Processes Processes Information pathways Information pathways Transport 52/6.22 59.5/4.875 63/6.2 15.5/2.82 38/7.51 40.5/6.885 45/5.72 45/8.05 27/4.48 41/6.58 42.5/3.96 30/5.885 93/5.43 69.5/5.Pyruvate dehydrogenase E1 component subunit beta, mitochondrialHydroxyacid oxidase217/Medium-chain specific acyl-CoA dehydrogenase, mitochondrialHomogentisate 1,2-dioxygenaseSarcosine dehydrogenase, mitochondrialBeta-lactamase-like proteinSerine/threonine-protein phosphatase PP1-alpha catalytic subunit317/CatalaseAldehyde dehydrogenase family 1 member L1 100/5.Alpha-aminoadipic semialdehyde dehydrogenase324/60 kDa heat shock protein, mitochondrialCoatomer subunit deltaATP synthase subunit delta, mitochondrialAlcohol dehydrogenase 23115181 [NADP+]Sorbitol dehydrogenaseIsovaleryl-CoA dehydrogenase, mitochondrial 42.5/6.Ornithine aminotransferase, mitochondrialCreatine kinase U-type, mitochondrialLactoylglutathione lyasePhosphotriesterase-related protein40S ribosomal protein SAProteasome subunit beta type-385/386/Meprin A subunit alphaSerum albuminProteomic of F Renal Metabolism in Micea Experimental molecular weight (kDa)/pI of protein spot in the gel (Mean of min. and max.) based on the coordinates of landmark proteins. bTheoretical molecular weight (kDa)/pI of theoretical protein. cNumber of peptides identified and score. dDifferences in expression in relation to 129P3/J mice (Q down-modulation; q up-modulation); Individual P value after ANOVA. eIdentification is based on protein ID from IPI (international protein index) protein database (http://www.uniprot.org/). fCategory of protein based on its primary biological function according to Rison (2000) [18]. doi:10.1371/journal.pone.0053261.tTable 2. Expression of differentially significant kidney proteins between 10 ppmF A/J vs 10 ppmF 129P3/J mice.a c bSpot n6. 15.5/2.82 40/6.625 42.5/5.94 43/8.25 42.5/6.6 45/5.72 42/6.11 34/6.415 43/9.1 35.5/4.915 38.5/5.675 52.5/6.34 58/7.445 53.5/5.68 37/5.905 28/8.615 37/5.505 41/5.535 43/6.715 45/5.72 42/6.015 27/4.48 27/4.55 69.5/4.645 26.5/10.135 59.5/5.73 89.5/5.5 99.5/3.99 49.5/5.445 57.5/4.76 69.5/5.42 39.3/6.0 20.7/5.25 23.3/5.1 56.5/5.3 25.3/8.88 54.3/5.7 77.2/5.9 92.5/4.74 47.2/5.6 51.9/5.2 65.9/5.53 13/403 7/85 16/362 11/187 24/515 13/554 9/109 15/635 45.8/5.7 43/6.3 33.1/5.54 7/216 12/535 10/255 7/245 37/365 36.4/5.7 10/705 28.5/7.78 13/353 51.7/5.0 4/188 52.5/5.9 13/374 59.7/7.7 6/103 55.9/6.0 13/374 37.4/5.9 9/122 q129 (0.018) q129(0.005) q129(0.032) q129(0.037) Q129(0.022) Q129(0.017) Q129(0.002) Q129(0.016) Q129(0.021) Q129(0.024) Q129(0.041) Q129(0.001) Q129(0.005) Q129(0.041) Q129(0.050) Q129(0.043) Q129(0.002) Q129(0.011) Q129(0.016) Q129(0.028) Q129(0.020) 35.3/5.3 9/488 q129(0.003) 49/8.2 3/107 q129(0.035) 32.8/6.1 8/181 q129(0.039) 44/6.0 2/66 q129(0.047) 50/7.9 8/142 q129(0.015) P97807 Q9DBL1 Q78JT3 Q9CZU6 Q91XE4 P62137 Q9DBF1 P24270 P17563 Q91V76 Q8BH95 P16125 Q9Z0S1 Q9JHI5 P29758 P11930 Q9CPU0 Q99PT1 Q9JIL4 Q9WTP7 P27773 P28825 Q91V38 Q99JY9 P21614 P07724 43/6.3 15/559 q129(0.047) P50247 43.6/7.7 15/541 q129(0.001) P45952 45.8/5.9 18/831 q129(0.013) Q99JW2 37.8/6.3 4/146 q129(0.016) Q8K157 51.7/5.0 4/188 q129(0.040) P56480 Metabolism Metabolism Metabolism Metabolism Metabolism Metabolism Metabolism Metabolism Metabolism ProcessesProteinMw (kDa)/pI Expt.
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