Product Name: C3orf15 Polyclonal Antibody
Applications: WB, IHC-P, IF(IHC-P)
Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human AAT1/C3orf15
Clonality: Polyclonal
CAS NO: 1088965-37-0
Product: PKI-402
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Synonyms: AAT 1; AAT-1; AAT1; AAT1 alpha; AAT1_HUMAN; AAT1alpha; AMY 1 associating protein expressed in testis 1; AMY-1-associating protein expressed in testis 1; Chromosome 3 open reading frame 15; MYCBP binding protein.
Background: The c-Myc proto-oncogene plays a significant role in cell proliferation, differentiation, transformation and apoptosis. A novel c-Myc binding protein, MYCBP (also designated AMY-1), binds to the transactivation domain of c-Myc and stimulates the activation of E-box-dependent transcription. MYCBP translocates from the cytoplasm to the nucleus during S phase when increased expression of c-Myc occurs. MYCBP and AAT-1 (AMY-1-associating protein expressed in testis 1) have been shown to associate with AKAP 149 and AKAP 84 in mitochondria of somatic cells and sperm, which suggests a role for MYCBP and AAT-1 in spermatogenesis. Expression of the AAT-1 gene is regulated by two different promoters, which result in various isoforms. One promoter generates expression of the AAT-1, AAT-1å, AAT-1∫ and AAT-1© isoforms, which are specifically expressed in testis, while the other promoter generates AAT-1L, AAT-1M and AAT-1S, which are differentially expressed.
PubMed ID:http://jpet.aspetjournals.org/content/274/1/249
Heme Oxygenase heme-oxygenase.com
Just another WordPress site
