Product Name: CARD14 Polyclonal Antibody
Applications: WB, IHC-P, IF(IHC-P)
Reactivity: Human, Mouse, Rat
Conjugation: Unconjugated
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human CARD14
Clonality: Polyclonal
CAS NO: 1365888-06-7
Product: Diiodohydroxyquinoline
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Synonyms: Bcl10 interacting MAGUK protein 2; Bimp 2; Bimp2; CARD 14; CARD containing MAGUK 2 protein; CARD containing MAGUK protein 2; Card maguk protein 2; Carma 2; Carma2; Caspase recruitment domain containing protein 14; Caspase recruitment domain family member 14; Caspase recruitment domain protein 14; CAR14_HUMAN.
Background: The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encoding distinct isoforms have been reported.
PubMed ID:http://jpet.aspetjournals.org/content/291/3/988
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