Product Name: CARD7 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated
Applications: IF(IHC-P)
Reactivity: Human, Mouse, Rat
Conjugation: ALEXA FLUOR® 647
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human CARD7/NALP1
Clonality: Polyclonal
CAS NO: 459147-39-8
Product: PU-WS13
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: LRR and PYD domains-containing protein 1; CARD 7; CARD7; Caspase recruitment domain protein 7; Caspase recruitment domain-containing protein 7; CLR17.1; Death effector filament forming Ced 4 like apoptosis protein; Death effector filament-forming ced-4-like apoptosis protein; DEFCAP; DEFCAP L/S; NAC alpha/beta/gamma/delta; NAC; NACHT; NACHT leucine rich repeat and PYD containing 1; NACHT leucine rich repeat and PYD pyrin domain containing 1; NACHT leucine rich repeat and pyrin domain containing 1; NACHT LRR and PYD containing protein 1; NALP 1; NALP1; NALP1_HUMAN; NLR family pyrin domain containing 1; NLRP 1; NLRP1; NLRP1 protein; Nucleotide binding domain and caspase recruitment domain; Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 1; Nucleotide-binding domain and caspase recruitment domain; PP 1044; PP1044.
Background: This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008].
PubMed ID:http://jpet.aspetjournals.org/content/292/1/67
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