Product Name: Caspase-10 Polyclonal Antibody, HRP Conjugated
Applications: WB, IHC-P
Reactivity: Human
Conjugation: HRP
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human Caspase-10
Clonality: Polyclonal
CAS NO: 212844-53-6
Product: Halothane
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store at 4°C for 12 months.
Synonyms: MCH4; ALPS2; FLICE2; Caspase-10; CASP-10; Apoptotic protease Mch-4; FAS-associated death domain protein interleukin-1B-converting enzyme 2; ICE-like apoptotic protease 4; CASP10
Background: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Isoform C is proteolytically inactive.
PubMed ID:http://jpet.aspetjournals.org/content/294/3/884
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