Product Name: Caspase-6 (NT) Polyclonal Antibody
Applications: WB, IHC-P, IF(IHC-P)
Reactivity: Human, Rat
Conjugation: Unconjugated
Host: Mouse
Sourcr: KLH conjugated synthetic peptide derived from human Caspase-6 subunit p18
Clonality: Polyclonal
CAS NO: 1191911-27-9
Product: Pheniramine (Maleate)
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Synonyms: Caspase-6 subunit p18; Caspase-6 p18; Apoptosis Related Cysteine Protease; Apoptotic cysteine protease MCH2; Apoptotic protease MCH 2; Apoptotic protease MCH2; Casp 6; Casp6; Caspase 6 apoptosis related cysteine protease; Caspase 6 precursor; Caspase6; Human cysteine protease Mch2 isoform alpha; Mch 2; Mch2; CASP6_HUMAN.
Background: Caspase-6 is involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Subunit is compose of heterodimer of a18 kDa (p18) and a 11 kDa (p11) subunit. Subcellular location at cytoplasmic. Cleavages by CPP32, caspase-8 or -10 generate the two active subunits. It belongs to the peptidase C14 family.
PubMed ID:http://jpet.aspetjournals.org/content/295/1/16
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