Product Name: Caspase 8 Polyclonal Antibody, Cy7 Conjugated
Applications: IF(IHC-P), IF(ICC)
Reactivity: Human, Mouse, Rat
Conjugation: Cy7
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from mouse Caspase-8 subunit p10
Clonality: Polyclonal
CAS NO: 1215085-93-0
Product: Ginkgolic Acid (C13:0)
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: MACH; Mch5; FLICE; CASP-8; Caspase-8; Casp8
Background: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP1. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein.
PubMed ID:http://jpet.aspetjournals.org/content/294/2/680
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