Product Name: Caspase 9 Polyclonal Antibody, PE Conjugated
Applications: FCM
Reactivity: Human, Mouse, Rat, Dog
Conjugation: PE
Host: Rabbit
Sourcr: KLH conjugated synthetic peptide derived from human Caspase 9 subunit p35
Clonality: Polyclonal
CAS NO: 6809-52-5
Product: Imidazolidinyl urea
Isotype: IgG
Concentration: 1ug/ul
Purification: Purified by Protein A.
Storage: Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Synonyms: MCH6; APAF3; APAF-3; PPP1R56; ICE-LAP6; Caspase-9; CASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; ICE-like apoptotic protease 6; CASP9
Background: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
PubMed ID:http://jpet.aspetjournals.org/content/294/3/1017
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