Product Name :
ML-098
Description:
ML-098, also known as CID-7345532, is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM). ML098 (CID-7345532) functions by increasing the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II. .
CAS:
878978-76-8
Molecular Weight:
309.36
Formula:
C19H19NO3
Chemical Name:
1-(2-(2,5-dimethylphenoxy)ethyl)-1H-indole-3-carboxylic acid
Smiles :
CC1C=C(OCCN2C=C(C(O)=O)C3=CC=CC=C23)C(C)=CC=1
InChiKey:
LILIWWFBJKBUCO-UHFFFAOYSA-N
InChi :
InChI=1S/C19H19NO3/c1-13-7-8-14(2)18(11-13)23-10-9-20-12-16(19(21)22)15-5-3-4-6-17(15)20/h3-8,11-12H,9-10H2,1-2H3,(H,21,22)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.{{Topiramate} medchemexpress|{Topiramate} Calcium Channel|{Topiramate} Protocol|{Topiramate} Formula|{Topiramate} custom synthesis|{Topiramate} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ML-098, also known as CID-7345532, is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM). ML098 (CID-7345532) functions by increasing the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II. .|Product information|CAS Number: 878978-76-8|Molecular Weight: 309.36|Formula: C19H19NO3|Synonym:|ML 098|CID-7345532|CID 7345532|ML-098|ML098|CID7345532|Chemical Name: 1-(2-(2,5-dimethylphenoxy)ethyl)-1H-indole-3-carboxylic acid|Smiles: CC1C=C(OCCN2C=C(C(O)=O)C3=CC=CC=C23)C(C)=CC=1|InChiKey: LILIWWFBJKBUCO-UHFFFAOYSA-N|InChi: InChI=1S/C19H19NO3/c1-13-7-8-14(2)18(11-13)23-10-9-20-12-16(19(21)22)15-5-3-4-6-17(15)20/h3-8,11-12H,9-10H2,1-2H3,(H,21,22)|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO, not in water|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|Probe compound mL098 (CID-7345532) functions by increasing the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II.{{IL-4 Protein, Mouse} MedChemExpress|{IL-4 Protein, Mouse} Purity & Documentation|{IL-4 Protein, Mouse} Purity|{IL-4 Protein, Mouse} custom synthesis|{IL-4 Protein, Mouse} Epigenetics} ML-098 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.PMID:24733396 6 nM which shows selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively).|References:|Surviladze Z, Ursu O, Miscioscia F, Curpan R, Halip L, Bologa C, Oprea T, Waller A, Strouse J, Salas V, Wu Y, Edwards B, Wandinger-Ness A, Sklar L. Three small molecule pan activator families of Ras-related GTPases. 2009 May 18 [updated 2010 Sep 2]. Probe Reports from the NIH Molecular Libraries Program [Internet].Products are for research use only. Not for human use.|
