Product Name :
IWP-O1
Description:
IWP-O1 is highly potent Porcn inhibitor, The acyltransferase Porcupine (Porcn) is essential for the secretion of Wnt proteins which contribute to embryonic development, tissue regeneration, and tumorigenesis. IWP-O1 has an EC50 value of 80pM in a cultured cell reporter assay of Wnt signaling. Additionally, IWP-O1 has significantly improved metabolic stability over our previously reported Porcn inhibitors.
CAS:
2074607-48-8
Molecular Weight:
432.48
Formula:
C26H20N6O
Chemical Name:
5-Phenyl-N-(5-phenylpyridin-2-yl)-4-(pyridin-4-yl)-1H-1,2,3-triazol-1-acetamide,
Smiles :
O=C(CN1N=NC(=C1C1C=CC=CC=1)C1C=CN=CC=1)NC1=CC=C(C=N1)C1C=CC=CC=1
InChiKey:
GYYDQHBKIHQHEB-UHFFFAOYSA-N
InChi :
InChI=1S/C26H20N6O/c33-24(29-23-12-11-22(17-28-23)19-7-3-1-4-8-19)18-32-26(21-9-5-2-6-10-21)25(30-31-32)20-13-15-27-16-14-20/h1-17H,18H2,(H,28,29,33)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Troglitazone} MedChemExpress|{Troglitazone} Apoptosis|{Troglitazone} Protocol|{Troglitazone} In stock|{Troglitazone} supplier|{Troglitazone} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.{{Telithromycin} site|{Telithromycin} Anti-infection|{Telithromycin} Technical Information|{Telithromycin} In Vivo|{Telithromycin} manufacturer|{Telithromycin} Epigenetics}
Stock Solution Storage:
Additional information:
IWP-O1 is highly potent Porcn inhibitor, The acyltransferase Porcupine (Porcn) is essential for the secretion of Wnt proteins which contribute to embryonic development, tissue regeneration, and tumorigenesis. IWP-O1 has an EC50 value of 80pM in a cultured cell reporter assay of Wnt signaling.PMID:24140575 Additionally, IWP-O1 has significantly improved metabolic stability over our previously reported Porcn inhibitors.|Product information|CAS Number: 2074607-48-8|Molecular Weight: 432.48|Formula: C26H20N6O|Chemical Name: 5-Phenyl-N-(5-phenylpyridin-2-yl)-4-(pyridin-4-yl)-1H-1,2,3-triazol-1-acetamide,|Smiles: O=C(CN1N=NC(=C1C1C=CC=CC=1)C1C=CN=CC=1)NC1=CC=C(C=N1)C1C=CC=CC=1|InChiKey: GYYDQHBKIHQHEB-UHFFFAOYSA-N|InChi: InChI=1S/C26H20N6O/c33-24(29-23-12-11-22(17-28-23)19-7-3-1-4-8-19)18-32-26(21-9-5-2-6-10-21)25(30-31-32)20-13-15-27-16-14-20/h1-17H,18H2,(H,28,29,33)|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|IWP-O1 (17) suppresses Wnt signaling in L-Wnt-STF cells with an EC50 value of 80 pM, 2.5 times more active than the investigational drug LGK974.|References:|You L, Zhang C, Yarravarapu N, Morlock L, Wang X, Zhang L, Williams NS, Lum L, Chen C. Development of a triazole class of highly potent Porcn inhibitors. BioorgMed Chem Lett. 2016 Dec 15;26(24):5891-5895. doi: 10.1016/j.bmcl.2016.11.012.Epub 2016 Nov 11. PubMed PMID: 27876319; PubMed Central PMCID: PMC5142825.Products are for research use only. Not for human use.|
