Product Name :
PBOX 6
Description:
PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound, acts as a microtubule-depolymerizing agent and an apoptotic agent.
CAS:
290814-68-5
Molecular Weight:
396.44
Formula:
C25H20N2O3
Chemical Name:
8-(naphthalen-1-yl)-9-oxa-2-azatricyclo[8.4.0.0²,⁶]tetradeca-1(14),3,5,7,10,12-hexaen-7-yl N,N-dimethylcarbamate
Smiles :
CN(C)C(=O)OC1=C(OC2=CC=CC=C2N2C=CC=C21)C1C=CC=C2C=CC=CC2=1
InChiKey:
SOIZAFVNIXAZFQ-UHFFFAOYSA-N
InChi :
InChI=1S/C25H20N2O3/c1-26(2)25(28)30-24-21-14-8-16-27(21)20-13-5-6-15-22(20)29-23(24)19-12-7-10-17-9-3-4-11-18(17)19/h3-16H,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PBOX 6 is a pyrrolo-1,5-benzoxazepine (PBOX) compound, acts as a microtubule-depolymerizing agent and an apoptotic agent.{{Acarbose} medchemexpress|{Acarbose} Glucosidase|{Acarbose} Biological Activity|{Acarbose} In Vivo|{Acarbose} custom synthesis|{Acarbose} Epigenetics} |Product information|CAS Number: 290814-68-5|Molecular Weight: 396.44|Formula: C25H20N2O3|Chemical Name: 8-(naphthalen-1-yl)-9-oxa-2-azatricyclo[8.4.0.0²,⁶]tetradeca-1(14),3,5,7,10,12-hexaen-7-yl N,N-dimethylcarbamate|Smiles: CN(C)C(=O)OC1=C(OC2=CC=CC=C2N2C=CC=C21)C1C=CC=C2C=CC=CC2=1|InChiKey: SOIZAFVNIXAZFQ-UHFFFAOYSA-N|InChi: InChI=1S/C25H20N2O3/c1-26(2)25(28)30-24-21-14-8-16-27(21)20-13-5-6-15-22(20)29-23(24)19-12-7-10-17-9-3-4-11-18(17)19/h3-16H,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PBOX 6 is a potent apoptotic PBOX, but does not elicit a general toxic effect in a rat R2C Leydig cell line.{{Ergothioneine} medchemexpress|{Ergothioneine} NF-κB|{Ergothioneine} Biological Activity|{Ergothioneine} In stock|{Ergothioneine} supplier|{Ergothioneine} Epigenetics} PBOX 6 (0-25 μM, 16 h) results in dose- and time-dependent induction of apoptosis, and also causes DNA fragmentation at 10 μM in HL-60 cells.PMID:34235739 PBOX 6 (10 μM) induces apoptosis through activation of caspase 3-like proteases in HL-60 cells. PBOX 6 (10 μM) induces apoptosis and exerts an accumulation of cytochromec in the cytosol, but this effect is not triggered by oxidative stress, and is independent of peripheral-type benzodiazepine receptor (PBR) and NF-κB. PBOX 6 (25 μM) induces apoptosis in MCF-7 cells through activation of caspase-7. PBOX 6 (10 μM) induces the redistribution of cypA from the nucleus to the cytosol of the cell in K562 cells. PBOX 6 (10 μM) induces nucleocytoplasmic redistribution of cypA and pin1 through a JNK-dependent manner, also dependent on upstream activation of a trypsin-like serine protease, and this effect correlates with G2/M arrest in K562 cells.|Products are for research use only. Not for human use.|
