Product Name :
L-778123 hydrochloride
Description:
L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.IC50 value: 2 nM Target: FPTasein vitro: L-778123 can completely inhibit Ki-Ras prenylation. L-778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti-cancer agent. in vivo: In the dog model, L-778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of unprenylatedRap1A in PBMCs.
CAS:
253863-00-2
Molecular Weight:
442.34
Formula:
C22H21Cl2N5O
Chemical Name:
4-[(5-{[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl}-1H-imidazol-1-yl)methyl]benzonitrile hydrochloride
Smiles :
Cl.N#CC1=CC=C(CN2C=NC=C2CN2CC(=O)N(CC2)C2C=C(Cl)C=CC=2)C=C1
InChiKey:
YNBSQYGTJLIPJS-UHFFFAOYSA-N
InChi :
InChI=1S/C22H20ClN5O.{{Veratridine} web|{Veratridine} Sodium Channel|{Veratridine} Technical Information|{Veratridine} Formula|{Veratridine} manufacturer|{Veratridine} Epigenetic Reader Domain} ClH/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18;/h1-7,10,12,16H,8-9,13-15H2;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
L-778123 hydrochloride is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.{{Oclacitinib} site|{Oclacitinib} Epigenetics|{Oclacitinib} Purity & Documentation|{Oclacitinib} In Vivo|{Oclacitinib} custom synthesis|{Oclacitinib} Autophagy} IC50 value: 2 nM Target: FPTasein vitro: L-778123 can completely inhibit Ki-Ras prenylation. L-778123 as a farnesyltransferase inhibitor can have a good cytotoxic activity as a classic anti-cancer agent. in vivo: In the dog model, L-778123 inhibits HDJ2 prenylation and produces measurable, albeit slight (5%), levels of unprenylatedRap1A in PBMCs.|Product information|CAS Number: 253863-00-2|Molecular Weight: 442.PMID:35670838 34|Formula: C22H21Cl2N5O|Chemical Name: 4-[(5-{[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl}-1H-imidazol-1-yl)methyl]benzonitrile hydrochloride|Smiles: Cl.N#CC1=CC=C(CN2C=NC=C2CN2CC(=O)N(CC2)C2C=C(Cl)C=CC=2)C=C1|InChiKey: YNBSQYGTJLIPJS-UHFFFAOYSA-N|InChi: InChI=1S/C22H20ClN5O.ClH/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18;/h1-7,10,12,16H,8-9,13-15H2;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 25 mg/mL (56.52 mM). H2O : 25 mg/mL (56.52 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
