Product Name :
MIRA-1
Description:
MIRA-1 is a maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline-regulated mutant p53 (IC50 = 10 µM in vitro).1 Treatment of tumor cells with MIRA-1 induces p21, MDM2 and PUMA in a mutant p53-dependent manner. At a concentration of 5-10 mg/kg, MIRA-1, alone or in combination with dexamethasone , arrested tumor growth in a mouse xenograft model of multiple myeloma.
CAS:
72835-26-8
Molecular Weight:
183.16
Formula:
C8H9NO4
Chemical Name:
(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propanoate
Smiles :
CCC(=O)OCN1C(=O)C=CC1=O
InChiKey:
YXEWPGYLMHXLPS-UHFFFAOYSA-N
InChi :
InChI=1S/C8H9NO4/c1-2-8(12)13-5-9-6(10)3-4-7(9)11/h3-4H,2,5H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MIRA-1 is a maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline-regulated mutant p53 (IC50 = 10 µM in vitro).{{Hygromycin B} site|{Hygromycin B} Activator|{Hygromycin B} Biological Activity|{Hygromycin B} Description|{Hygromycin B} supplier} 1 Treatment of tumor cells with MIRA-1 induces p21, MDM2 and PUMA in a mutant p53-dependent manner. At a concentration of 5-10 mg/kg, MIRA-1, alone or in combination with dexamethasone , arrested tumor growth in a mouse xenograft model of multiple myeloma.|Product information|CAS Number: 72835-26-8|Molecular Weight: 183.{{Mepolizumab} medchemexpress|{Mepolizumab} Interleukin Related|{Mepolizumab} Purity & Documentation|{Mepolizumab} In Vivo|{Mepolizumab} manufacturer|{Mepolizumab} Cancer} 16|Formula: C8H9NO4|Chemical Name: (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propanoate|Smiles: CCC(=O)OCN1C(=O)C=CC1=O|InChiKey: YXEWPGYLMHXLPS-UHFFFAOYSA-N|InChi: InChI=1S/C8H9NO4/c1-2-8(12)13-5-9-6(10)3-4-7(9)11/h3-4H,2,5H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23618405 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
