Product Name :
Thalidomide-5-OH
Description:
Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs.
CAS:
64567-60-8
Molecular Weight:
274.23
Formula:
C13H10N2O5
Chemical Name:
2-(2, 6-dioxopiperidin-3-yl)-5-hydroxy-2, 3-dihydro-1H-isoindole-1, 3-dione
Smiles :
OC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O
InChiKey:
LJBQRRQTZUJWRC-UHFFFAOYSA-N
InChi :
InChI=1S/C13H10N2O5/c16-6-1-2-7-8(5-6)13(20)15(12(7)19)9-3-4-10(17)14-11(9)18/h1-2,5,9,16H,3-4H2,(H,14,17,18)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs.|Product information|CAS Number: 64567-60-8|Molecular Weight: 274.23|Formula: C13H10N2O5|Chemical Name: 2-(2, 6-dioxopiperidin-3-yl)-5-hydroxy-2, 3-dihydro-1H-isoindole-1, 3-dione|Smiles: OC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O|InChiKey: LJBQRRQTZUJWRC-UHFFFAOYSA-N|InChi: InChI=1S/C13H10N2O5/c16-6-1-2-7-8(5-6)13(20)15(12(7)19)9-3-4-10(17)14-11(9)18/h1-2,5,9,16H,3-4H2,(H,14,17,18)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 62.{{Sacubitril/Valsartan} medchemexpress|{Sacubitril/Valsartan} GPCR/G Protein|{Sacubitril/Valsartan} Biological Activity|{Sacubitril/Valsartan} Description|{Sacubitril/Valsartan} manufacturer|{Sacubitril/Valsartan} Cancer} 5 mg/mL (227.{{Neratinib} medchemexpress|{Neratinib} JAK/STAT Signaling|{Neratinib} Biological Activity|{Neratinib} Formula|{Neratinib} custom synthesis|{Neratinib} Epigenetic Reader Domain} 91 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32543299 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Megan G Marks, et al. Effects of Putative Hydroxylated Thalidomide Metabolites on Blood Vessel Density in the Chorioallantoic Membrane (CAM) Assay and on Tumor and Endothelial Cell Proliferation. Biol Pharm Bull. 2002 May;25(5):597-604.Products are for research use only. Not for human use.|
