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Product Name :
Anti-INSR, Human antibody

Applications:
ELISA,Flow Cyt

Reactivity :
Human

Conjugate:
Unconjugated

Advantages :
High lot-to-lot consistencyIncreased sensitivity and higher affinityAnimal-free production

Description:
| Description: Anti-INSR, Human antibody is designed for detecting human INSR specifically. Based on ELISA and/or FCM, Anti-INSR, Human antibody reacts with human INSR specifically. | Immunogen: Recombinant human INSR | Host: Alpaca pacous | Isotype: Human IgG1 | Conjugate: Unconjugated | Specificity: Human INSR | Purity: Recombinant Expression and Affinity purified | Concentration: 1mg/ml | Formation: Liquid, 10mM PBS (pH 7.5), 0.05% sucrose, 0.1% trehalose, 0.01% proclin300, 50% Glycerol | Storage: Store at –20 °C, (Avoid freeze / thaw cycles) | Background:INSR (insulin receptor, IR) is a heterodimeric protein complex that has an intracellular beta subunit and an extracellular alpha subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are the cause of various insulin resistance syndromes and IGF-1R defects may also cause some forms of growth retardation.

Description2 :
Anti-INSR, Human antibody is designed for detecting human INSR specifically. Based on ELISA and/or FCM, Anti-INSR, Human antibody reacts with human INSR specifically.{{439083-90-6} site|{439083-90-6} Technical Information|{439083-90-6} Description|{439083-90-6} manufacturer}

Immunogen:
Recombinant human INSR

Host :
Alpaca pacous

Isotype:
Human IgG1

Purity :
Recombinant Expression and Affinity purified

Buffer :

Storage :
Store at –20 °C, (Avoid freeze / thaw cycles)

Function:
ELISA: 1:4,000-1:10000Flow Cytometry:1:200-1:1000Dilution factors are presented in the form of a range because the optimal dilution is a function of many factors, such as antigen density, permeability, etc.{{219685-50-4} MedChemExpress|{219685-50-4} Protocol|{219685-50-4} In Vivo|{219685-50-4} supplier} The actual dilution used must be determined empirically.PMID:31356039

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Author: heme -oxygenase