Product Name :
Rp-8-CPT-cAMPS
Description:
Rp-8-CPT-cAMPS, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI.
CAS:
129735-01-9
Molecular Weight:
487.88
Formula:
C16H15ClN5O5PS2
Chemical Name:
(2R, 4aR, 6R, 7R, 7aS)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-hydroxy-2-sulfanyl-hexahydro-2-furo[3, 2-d][1, 3, 2]dioxaphosphinin-2-one
Smiles :
NC1=NC=NC2=C1N=C(SC1C=CC(Cl)=CC=1)N2[C@@H]1O[C@@H]2CO[P@@](=O)(S)O[C@H]2[C@H]1O
InChiKey:
IVNQJYQKSYRLTE-FUWBYEKLSA-N
InChi :
InChI=1S/C16H15ClN5O5PS2/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(26-15)5-25-28(24,29)27-12/h1-4,6,9,11-12,15,23H,5H2,(H,24,29)(H2,18,19,20)/t9-,11-,12-,15-,28-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Rp-8-CPT-cAMPS, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI.|Product information|CAS Number: 129735-01-9|Molecular Weight: 487.88|Formula: C16H15ClN5O5PS2|Chemical Name: (2R, 4aR, 6R, 7R, 7aS)-6-{6-amino-8-[(4-chlorophenyl)sulfanyl]-9H-purin-9-yl}-7-hydroxy-2-sulfanyl-hexahydro-2-furo[3, 2-d][1, 3, 2]dioxaphosphinin-2-one|Smiles: NC1=NC=NC2=C1N=C(SC1C=CC(Cl)=CC=1)N2[C@@H]1O[C@@H]2CO[P@@](=O)(S)O[C@H]2[C@H]1O|InChiKey: IVNQJYQKSYRLTE-FUWBYEKLSA-N|InChi: InChI=1S/C16H15ClN5O5PS2/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(26-15)5-25-28(24,29)27-12/h1-4,6,9,11-12,15,23H,5H2,(H,24,29)(H2,18,19,20)/t9-,11-,12-,15-,28-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Tirapazamine} medchemexpress|{Tirapazamine} DNA/RNA Synthesis|{Tirapazamine} Protocol|{Tirapazamine} Description|{Tirapazamine} supplier|{Tirapazamine} Cancer} |Shelf Life: ≥12 months if stored properly.{{L-Glutamine} web|{L-Glutamine} Neuronal Signaling|{L-Glutamine} Technical Information|{L-Glutamine} In Vitro|{L-Glutamine} custom synthesis|{L-Glutamine} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:31613530 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Rp-8-CPT-cAMPS (100 μM; 15 min) blocks phosphorylation of VASP by 6-Bnz-cAMP and largely reduces VASP phosphorylation by forskolin and fenoterol. Rp-8-CPT-cAMPS (100 μM; 30 min) reduces GTP-loading of Rap1 by both 8-pCPT-2′-O-Me-cAMP and 6-Bnz-cAMP. Rp-8-CPT-cAMPS (100 μM; 30 min) largely diminishes the augmentation of bradykinin-induced IL-8 release by the PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2′-O-Me-cAMP. Rp-8-CPT-cAMPS (10 μM) inhibits the endothelium-dependent and -independent relaxation which induced by Venom in pre-contracted rat mesenteric artery rings.|References:|Dostmann WR , et, al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3′,5′-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91.Roscioni SS, et, al. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. Respir Res. 2009 Sep 29;10(1):88.Products are for research use only. Not for human use.|
