Product Name :
CR-1-31-B
Description:
CR-1-31-B is a potent eIF4A RNA helicase inhibitor. CR-1-31-B blocks MUC1-C translation in response to growth factor stimulation in breast cancer cells.
CAS:
1352914-52-3
Molecular Weight:
507.53
Formula:
C28H29NO8
Chemical Name:
(2S,3R,4R,5S,6R)-2,3-dihydroxy-N,10,12-trimethoxy-6-(4-methoxyphenyl)-5-phenyl-7-oxatricyclo[6.4.0.0²,⁶]dodeca-1(12),8,10-triene-4-carboxamide
Smiles :
COC1C=C(C=C2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)C=12)C(=O)NOC)C1C=CC=CC=1)C1C=CC(=CC=1)OC)OC
InChiKey:
KLSIFOJPWJBRFH-GWNOIRNCSA-N
InChi :
InChI=1S/C28H29NO8/c1-33-18-12-10-17(11-13-18)28-23(16-8-6-5-7-9-16)22(26(31)29-36-4)25(30)27(28,32)24-20(35-3)14-19(34-2)15-21(24)37-28/h5-15,22-23,25,30,32H,1-4H3,(H,29,31)/t22-,23-,25-,27+,28+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CR-1-31-B is a potent eIF4A RNA helicase inhibitor. CR-1-31-B blocks MUC1-C translation in response to growth factor stimulation in breast cancer cells.|Product information|CAS Number: 1352914-52-3|Molecular Weight: 507.53|Formula: C28H29NO8|Chemical Name: (2S,3R,4R,5S,6R)-2,3-dihydroxy-N,10,12-trimethoxy-6-(4-methoxyphenyl)-5-phenyl-7-oxatricyclo[6.4.0.0²,⁶]dodeca-1(12),8,10-triene-4-carboxamide|Smiles: COC1C=C(C=C2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)C=12)C(=O)NOC)C1C=CC=CC=1)C1C=CC(=CC=1)OC)OC|InChiKey: KLSIFOJPWJBRFH-GWNOIRNCSA-N|InChi: InChI=1S/C28H29NO8/c1-33-18-12-10-17(11-13-18)28-23(16-8-6-5-7-9-16)22(26(31)29-36-4)25(30)27(28,32)24-20(35-3)14-19(34-2)15-21(24)37-28/h5-15,22-23,25,30,32H,1-4H3,(H,29,31)/t22-,23-,25-,27+,28+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 230 mg/mL (453.{{Methimazole} medchemexpress|{Methimazole} Biological Activity|{Methimazole} In Vitro|{Methimazole} custom synthesis|{Methimazole} Epigenetic Reader Domain} 18 mM; Need ultrasonic).{{Ergothioneine} web|{Ergothioneine} NF-κB|{Ergothioneine} Technical Information|{Ergothioneine} In Vitro|{Ergothioneine} manufacturer|{Ergothioneine} Autophagy} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32090672 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CR-1-31-B (100 nM; 24 hours) inhibits MUC1-C translation in MCF-10A cells. CR-1-31-B (10 and 100 nM) decreases MUC1-C abundance in MDA-MB-468 breast cancer cells.|Products are for research use only. Not for human use.|
