Product Name :
Humanin (human)
Sequence:
H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH
Purity:
≥98% (HPLC)
Molecular Weight:
2687.3
Solubility :
Soluble in DMSO or 5% acetic acid.
Appearance:
White to off-white powder.
Use/Stability :
As indicated on product label or CoA when stored as recommended.
Description:
Bax inhibitor Humanin was originally identified as an anti-apoptotic peptide of 24 aa encoded in a cDNA that rescued neuronal cells from apoptosis induced by presenilin mutants associated with familial Alzheimer’s disease and by amyloid-β protein. Mutagenesis studies showed that the cysteine at position 8 of the humanin peptide is critical for its anti-apoptotic function. It has now been shown that Bax (Bcl-2 associated X protein), an apoptosis-inducing protein, interacts with humanin.{{1613509-49-1} site|{1613509-49-1} Purity & Documentation|{1613509-49-1} In stock|{1613509-49-1} manufacturer} Humanin prevents the translocation of Bax from the cytosol to mitochondria. Humanin peptides also block Bax association with isolated mitochondria, and suppress cytochrome c release in vitro.
CAS :
330936-69-1
Solubility:
Soluble in DMSO or 5% acetic acid.{{2374971-81-8} site|{2374971-81-8} Technical Information|{2374971-81-8} Purity|{2374971-81-8} supplier}
Formula:
C119H204N34O32S2
Additional Information :
| Appearance White to off-white powder.PMID:31264396 | CAS 330936-69-1 | Formula C119H204N34O32S2 | MW 2687.3 | Purity ≥98% (HPLC) | Sequence H-Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala-OH | Solubility Soluble in DMSO or 5% acetic acid.
