Product Name :
Itraconazole
Sequence:
Purity:
≥98% (HPLC)
Molecular Weight:
705.6
Solubility :
Soluble in DMSO (1.5 mg/ml, warm).
Appearance:
White solid.
Use/Stability :
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored unopened at -20°C
Description:
CYP 14-α demethylase inhibitor. Autophagy inducer. Inhibits 14-α demethylase, a cytochrome P-450 enzyme, thus blocking conversion of lanosterol to ergosterol. Itraconazole inhibits glioblastoma cell proliferation in vitro and in vivo, and stimulates autophagic progression through inhibition of cholesterol trafficking from late endosomes and lysosomes to the plasma membrane. Binds Smoothened (SMO) via a mechanism distinct from that of cyclopamine, inhibiting the Hedgehog pathway. Also inhibits angiogenesis via blocking the binding of VEGF to VEGFR2.
CAS :
84625-61-6
Solubility:
Soluble in DMSO (1.5 mg/ml, warm).{{2762552-74-7} medchemexpress|{2762552-74-7} Protocol|{2762552-74-7} References|{2762552-74-7} custom synthesis}
Formula:
C35H36Cl2N8O4
Additional Information :
| Alternative Name Oriconazole, R51211 | Appearance White solid.{{1443553-08-9} web|{1443553-08-9} Biological Activity|{1443553-08-9} Description|{1443553-08-9} manufacturer} | CAS 84625-61-6 | Couple Target Cytochrome P450 | Couple Type Inhibitor | Formula C35H36Cl2N8O4 | Formulation Lyophilized.PMID:29494043 | Identity Identity determined by NMR. | MW 705.6 | Purity ≥98% (HPLC) | Solubility Soluble in DMSO (1.5 mg/ml, warm). | Unit of Measure (UM) mg
