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p53 Recombinant monoclonal antibody (TP53/1799R)
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p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia.{{909110-25-4} MedChemExpress|{909110-25-4} Biological Activity|{909110-25-4} References|{909110-25-4} custom synthesis} Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.{{1219168-18-9} MedChemExpress|{1219168-18-9} Technical Information|{1219168-18-9} Purity|{1219168-18-9} manufacturer}
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| Alternative Name TRP53, Tumor protein p53 | Application Flow Cytometry, IF, IHC (PS), WB | Clone TP53/1799R | Formulation Liquid.PMID:29763130 In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. | Host Rabbit | Immunogen Recombinant human p53. | Isotype IgGκ | Recommendation Dilutions/Conditions Flow Cytometry (0.5-1 µg/106 cells in 0.1 mL)Immunofluorescence (0.5-1 µg/mL)Immunohistochemistry (formalin-fixed paraffin sections) (0.25-0.5 µg/mL for 30 minutes at RT)Western blot (0.5-1 µg/mL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Species Reactivity Human | Specificity Recognizes the mutant as well as the wild form of p53. | UniProt ID P04637 | Unit of Measure (UM) µg
