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TROP2 (human) monoclonal antibody (01)
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Trop-2 (tumor-associated calcium signal transducer 2) is a 46-48kDa cell surface glycoprotein that acts as a calcium signal transducer. The molecule is expressed at high levels in human throphoblasts and overexpressed on a large variety of human carcinomas (including breast, colon, lung and prostate cancers). As an example, Trop-2 is among the most highly overexpressed genes in primary ovarian serous papillary tumors compared to normal ovarian epithelium and in in colon tumors compared with normal mucosa. Trop-2 is homologous to Trop-1 and both are homologous to serum IGF-II-binding proteins. The specific role of Trop-2 in normal and tumor cells is not fully defined, but accumulating evidence suggests a regulatory role in the growth of carcinoma cells.1229022-83-6 site Furthermore there is data supporting the hypothesis that Trop-2 is involved in tumor invasion and metastasis.122111-03-9 Protocol Indeed, TROP2 is one of the cancer-related genes that correlates with biological aggressiveness and poor prognosis of colorectal cancer.
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| Alternative Name Tumor associated calcium signal transducer 2, GA733-1, M1S1, TACSTD2 | Application ELISA, Flow Cytometry, IHC (PS) | Clone 01 | Crossreactivity Does not cross-react with mouse or rat TROP2.PMID:25905391 | Formulation Liquid. 0.2 µM filtered solution in PBS. | Host Mouse | Immunogen Recombinant human TROP2 extracellular domain. | Isotype IgG1 | Species Reactivity Human | UniProt ID P09758 | Unit of Measure (UM) µl
