Product Name :
LY88074
Description:
LY88074 (Compound 88074) is a Raloxifene analog lacking the basic side chain. Raloxifene is a selective estrogen receptor modulator, and reduces fracture risk at least in part by improving the mechanical properties of bone in a cell- and estrogen receptor-independent manner.
CAS:
177744-96-6
Molecular Weight:
362.40
Formula:
C21H14O4S
Chemical Name:
3-(4-hydroxybenzoyl)-2-(4-hydroxyphenyl)-1-benzothiophen-6-ol
Smiles :
OC1C=CC(=CC=1)C(=O)C1=C(SC2=CC(O)=CC=C21)C1C=CC(O)=CC=1
InChiKey:
CTMKIRXPVZYQJP-UHFFFAOYSA-N
InChi :
InChI=1S/C21H14O4S/c22-14-5-1-12(2-6-14)20(25)19-17-10-9-16(24)11-18(17)26-21(19)13-3-7-15(23)8-4-13/h1-11,22-24H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
LY88074 (Compound 88074) is a Raloxifene analog lacking the basic side chain. Raloxifene is a selective estrogen receptor modulator, and reduces fracture risk at least in part by improving the mechanical properties of bone in a cell- and estrogen receptor-independent manner.|Product information|CAS Number: 177744-96-6|Molecular Weight: 362.40|Formula: C21H14O4S|Chemical Name: 3-(4-hydroxybenzoyl)-2-(4-hydroxyphenyl)-1-benzothiophen-6-ol|Smiles: OC1C=CC(=CC=1)C(=O)C1=C(SC2=CC(O)=CC=C21)C1C=CC(O)=CC=1|InChiKey: CTMKIRXPVZYQJP-UHFFFAOYSA-N|InChi: InChI=1S/C21H14O4S/c22-14-5-1-12(2-6-14)20(25)19-17-10-9-16(24)11-18(17)26-21(19)13-3-7-15(23)8-4-13/h1-11,22-24H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.VAL-083 medchemexpress |Shelf Life: ≥12 months if stored properly.Olanzapine MedChemExpress |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32552136 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Removal of the aminoethylpiperdine moiety, as in LY88074 (Compound 88074), reduces bone binding, compared to Raloxifene. The interaction of LY88074 with collagen matrix, although significant, is less than the interaction found with Raloxifene.|References:|Bivi N, et al. Structural features underlying raloxifene’s biophysical interaction with bone matrix. Bioorg Med Chem. 2016 Feb 15;24(4):759-67.Products are for research use only. Not for human use.|
